Features Of Immune Status In COVID-19 Convalescents

Study objective — assessment of the humoral and cell-mediated immunity features in COVID-19 convalescents three months after their discharge from hospital. Material Methods The study involved 78 who, depending on profile specific IgM IgG antibodies to SARS-CoV-2, were divided into groups. control group consisted 50 volunteers. Detection blood serum was performed by ELISA. Determination CRP concentration conducted using immunoturbidimetric assay. To determine levels IL-6, a sandwich version solid-phase ELISA employed. Immunophenotyping lymphocytes via flow cytometry. Results Of hospital, 30.8% them had IgM(+)IgG(+), 37.2% IgM(-)IgG(+), 32.0% characterized IgM(-)IgG (-). with an IgM(-)IgG(-) highest NK cells, T helper B (p<0.001) hyperproduction proinflammatory IL-6 (p<0.001). IgM(+)IgG(+) antibody cytotoxic In convalescent IgM(-)IgG(+) profile, we observed increase number expressing late activation/apoptosis molecules Conclusion collected data is potential importance clinical practice for developing prognosis epidemiological situation development, as well planning preventive measures COVID-19.